INCREASED YIELD OF F-VIII FROM POOLED PLASMA VS SINGLE-DONOR PLASMA IN THE PRODUCTION OF CRYOPRECIPITATES

Citation
Z. Racz et al., INCREASED YIELD OF F-VIII FROM POOLED PLASMA VS SINGLE-DONOR PLASMA IN THE PRODUCTION OF CRYOPRECIPITATES, Archives of medical research, 28(2), 1997, pp. 179-182
Citations number
33
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
01884409
Volume
28
Issue
2
Year of publication
1997
Pages
179 - 182
Database
ISI
SICI code
0188-4409(1997)28:2<179:IYOFFP>2.0.ZU;2-1
Abstract
Coagulation factor VIII:C yield was studied in two types of cryoprecip itates. The first group contained products from single-donor plasma un its. The other group contained cryoprecipitates which were produced fr om pooled plasma. The volume of plasma/bag was not different between t he two groups, but both the yield and the total content of F VIII:C in cryoprecipitates were significantly different. The yield of F VIII:C was higher (+ 20% in relative terms) in cryoprecipitates produced from pooled plasma, resulting in higher potency of such products. The posi tive effect of plasma pooling on the recovery of F VIII:C might be a r esult of reassembly of factor VIII subunits of different individuals i n the plasma pools. The findings may have a role also in large-scale p roduction of F VIII concentrates.