INCREASED YIELD OF F-VIII FROM POOLED PLASMA VS SINGLE-DONOR PLASMA IN THE PRODUCTION OF CRYOPRECIPITATES

Coagulation factor VIII:C yield was studied in two types of cryoprecip itates. The first group contained products from single-donor plasma un its. The other group contained cryoprecipitates which were produced fr om pooled plasma. The volume of plasma/bag was not different between t he two groups, but both the yield and the total content of F VIII:C in cryoprecipitates were significantly different. The yield of F VIII:C was higher (+ 20% in relative terms) in cryoprecipitates produced from pooled plasma, resulting in higher potency of such products. The posi tive effect of plasma pooling on the recovery of F VIII:C might be a r esult of reassembly of factor VIII subunits of different individuals i n the plasma pools. The findings may have a role also in large-scale p roduction of F VIII concentrates.