Nicotine consumption of several mouse strains using a two bottle choice paradigm

The two bottle choice paradigm provides a convenient method for the rapid s creening of preferences of nicotine and a variety of other substances in ro dents. A non-expensive, home-made bottle system with low fluid loss due to leakage or evaporation is introduced. Using this system, we tested nicotine preference of the mouse strains NMRI, C3H/J, DBA/2, ST/bJ, C57BL/6 and a c ross between male A/J and female NMRI. Our results show different nicotine preference of tested mice with high nicotine preference of C57BL/6, a lower preference of C3H/J, A/JxNMRI, DBA/2 and NMRI and the lowest of ST/bJ.