Improvements in the synthesis of terminal alkynes via coupling of arylbromides with 2-methylbut-3-yn-2-ol

Authors
Menchi, G Scrivanti, A Matteoli, U
Citation
G. Menchi et al., Improvements in the synthesis of terminal alkynes via coupling of arylbromides with 2-methylbut-3-yn-2-ol, J MOL CAT A, 152(1-2), 2000, pp. 77-82
Citations number
19
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
ISSN journal
13811169 → ACNP
Volume
152
Issue
1-2
Year of publication
2000
Pages
77 - 82
Database
ISI
SICI code
1381-1169(20000301)152:1-2<77:IITSOT>2.0.ZU;2-J
Abstract
The palladium/copper (Pd/Cu)-catalyzed cross-coupling of bromobenzene and 2 -methylbut-3-yn-2-ol has been investigated to ascertain the factors influen cing the reaction rate. Most usefully; the reaction is carried out using Pd (acetate), as catalyst precursor in combination with PPh3 and a copper salt . A primary or: a cyclic amine is best suited as the reaction solvent. Unde r these conditions, substrate to palladium ratios of 2000 can be used. (C) 2000 Elsevier Science B.V. All rights reserved.