Acetophenone-based linker for solid-phase peptide synthesis

Authors
Bui, CT Bray, AM Nguyen, T Ercole, F Rasoul, F Sampson, W Maeji, NJ
Citation
Ct. Bui et al., Acetophenone-based linker for solid-phase peptide synthesis, J PEPT SCI, 6(2), 2000, pp. 49-56
Citations number
19
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF PEPTIDE SCIENCE
ISSN journal
10752617 → ACNP
Volume
6
Issue
2
Year of publication
2000
Pages
49 - 56
Database
ISI
SICI code
1075-2617(200002)6:2<49:ALFSPS>2.0.ZU;2-F
Abstract
A new and cost-effective linker for the generation of carboxylic acid end g roups on Multipin supports (SynPhase(TM) crowns) has been developed. Synthe sis of the linker was based on modification of grafted polystyrene (PS) cro wns to generate a hydroxyethyl moiety which is acid labile in 10-20% triflu oroacetic acid (TFA) in dichloromethane (DCM). Solid-phase syntheses of mod el decapeptides using this Linker are described. Copyright (C) 2000 Europea n Peptide Society and John Wiley & Sons, Ltd.