Lymphatic transport of proteins after subcutaneous administration

This mini-review summarizes the relevant literature regarding the lymphatic transport of proteins after subcutaneous administration. A review of the p hysiology of the lymphatics and inherent anatomical differences between blo od and lymph capillaries is presented followed by a brief overview of the g eneral characteristics of protein absorption and bioavailability following S.C. injection. A description of factors known to directly affect the lymph atic uptake of macromolecules follows and is supported by representative da ta from this laboratory. A brief perspective on the importance of lymphatic uptake and transport in understanding the biopharmaceutical properties of protein drugs and potentially targeting the lymphatics is presented. (C) 20 00 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 89: 297-810, 2000.