E. Welzl-hinterkorner et A. Tholen, Bilateral cystoid macular edema in acute tubulointerstitial nephritis and uveitis (TINU), KLIN MONATS, 216(2), 2000, pp. 116-117
Background: TINU - Syndrome (Acute tubulointerstitial nephritis and uveitis
) is a rare immune-mediated disease, primarily occurring in children and yo
ung women. Uveitis may precede, follow or occur concomitantly with nephriti
s. Corticosteroids are the mainstay of therapy.
Patient: A 73-year old female patient with tubulointerstitial nephritis and
recurrences of anterior uveitis was diagnosed having TINU syndrome. During
follow-up she developed bilateral cystoid macular edema with accompanying
visual loss. Nephritis and uveitis responded well to oral corticosteroids.
Conclusions: Uveitis screening should exclude renal disease independent of
the age of the patient. Diagnosis can often be inferred from anamnesis, phy
sical examination, or laboratory tests. Renal biopsy as the most definite m
ethod of diagnosis may be necessary. Ophthalmologic follow-up on a regular
basis is mandatory for a successful management of long-term complications.