The effects of independently varying both wall shear stress (tau(w)) and tr
ansmembrane pressure (TMP) on permeate flux and fouling during ultrafiltrat
ion of reconstituted skimmed milk in total recycle mode have been investiga
ted. Irreversible fouling resistance (R-if) increased as TMP increased. Inc
reasing tau(w) at constant TMP led to an increase in both the initial flux,
and subsequent flux decline, and to a decrease in R-if. At the highest tau
(w), increasing TMP resulted in greater initial flux accompanied by increas
ing rates of flux decline and more irreversible fouling. Increasing and the
n decreasing TMP in a controlled, stepwise manner at constant tau(w) sugges
ted that flux is governed by both a reversible, and an irreversible fouling
layer which forms at higher TMP; this also controlled the transmission of
protein. Critical operating conditions producing the least fouling were eva
luated during this procedure.