14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis

The eventual recovery of patients with acute transverse myelitis is variabl e and can be difficult to predict on the basis of the presenting clinical a nd radiographic features. We find that an early accumulation of the 14-3-3 protein occurs exclusively in the cerebrospinal fluid of patients who show little or no recovery of neurological function and therefore could serve as a helpful prognostic indicator in this disorder.