Exacerbation of vascular endothelial injury in the generalized Shwartzman reaction by the administration of anti-E-selectin antibody

Previously, we reported that the consecutive administration of lipopolysacc haride (LPS) into LPS-sensitized mice for the generalized Shwartzman reacti on (GSR) induced systemic injury of vascular endothelial cells, The aim of this study was to investigate the participation of vascular adhesion molecu les in the vascular endothelial injury of GSR, The administration of anti-E -selectin antibody in GSR-induced mice resulted in massive apoptosis of vas cular endothelial cells and congestion in blood vessels, Further, marked he morrhage was found in the pulmonary alveoli of those mice, GSR, especially lung injury, was definitely exacerbated by the administration of anti-E-sel ectin antibody, On the other hand, the administration of anti-VCAM-1 antibo dy did not induce such injury of vascular endothelial cells. The possible r ole of E-selectin in the exacerbation of vascular endothelial injury in GSR is discussed.