Haemodynamic and acid-base changes during laparoscopic and open cholecystectomy: an experimental study

The aim of this study was to analyse and compare prospectively the haemodyn amic and acid-base changes during laparoscopic and open cholecystectomy in experimental animals. Nineteen pigs were randomised to undergo either lapar oscopic (group A, n = 10) or open (group B, n = 9) cholecystectomy. In grou p A, heart rate (HR), mean pulmonary arterial pressure (PAP), mean arterial pressure (MAP) and PCO2 levels, were statistically significantly increased (p < 0.05), while stroke volume (SV) and arterial pH were statistically si gnificantly decreased (p < 0.01). In group B, these parameters did not vary significantly. In both groups, cardiac output (CO), central venous pressur e (CVP), pulmonary arterial wedge pressure (PAWP) and total peripheral resi stance (TPR) did not change significantly. In conclusion, these findings su ggest that laparoscopic cholecystectomy might result in more cardiovascular and acid-base impairments than open cholecystectomy.