Immediate thallium re-injection after stress imaging for the detection of myocardial viability

Myocardial perfusion imaging with thallium is an established method to asse ss the presence of ischaemic and viable myocardium. Using planar imaging, i mages acquired 1 h after immediate thallium re-injection have been shown to be comparable to those of 3 h redistribution. The aim of this study was to clarify this using SPET. Twenty patients with chronic coronary artery dise ase with at least two perfusion defects on post-exercise images participate d in this study. All patients received thallium re-injection after post-str ess SPET and all had 1 h, 3 h and 24 h redistribution imaging. The thallium myocardial tomograms were divided into 14 segments for each patient. A tot al of 78 segments were studied. When the frequency of reversibility on 1 h, 3 h and 24 h redistribution images is compared, of the 78 SPET defects 18 (23.1%) showed reversibility by 1 h, 34 (43.6%) by combined Ih and 3 h imag ing (P < 0.05) and 50 (64.1%) by combined 1 h, 3 h and 24 h imaging (P < 0. 05). Our results show that, compared to 3 h images, images acquired 1 h aft er immediate thallium re-injection underestimate the extent of viable myoca rdial segments and the incidence of late reversibility was not reduced by t he immediate re-injection of thallium. ((C) 2000 Lippincott Williams & Wilk ins).