Tympanostomy tubes and otic suspensions: Do they reach the middle ear space?

The treatment of patients with tympanostomy tubes (TTs) and otorrhea with m edicated otic suspensions is well known, but confirmation of penetration in to the middle ear is difficult. To address this question, we created an in vitro model of the human head and ear and then tested if with 5 different t ypes of liquid exposure: tap water, soapy wafer, polymyxin B sulfate (Corti sporin), tobramycin and dexamethasone (TobraDex), and ciprofloxacin (Cipro) suspensions. A positive test result corresponded to liquids entering the m iddle ear through the TT, No positive test result was elicited with tap wat er (0/20), but soapy water did enter the middle ear (10/40) and was statist ically significant (P = 0.0112). Without the use of slight tragal pressure, Cortisporin, TobraDex, and Cipro drops did not consistently pass through t he TT (0/20, 1/25, 1/25). By placing the drops with the addition of tragal pressure, a statistically significant difference was obtained for each solu tion (20/20; 20/20, and 20/20, respectively (P < 0.0001)). We conclude that with a clean external auditory canal, patent TT, and no middle ear fluid, medicated otic suspensions enter the middle ear only when combined with sli ght tragal pressure.