We consider non-perturbative effects at short distances in theories with co
nfinement. The analysis is straightforward within the Abelian models in whi
ch the confinement arises on classical level. In all cases considered (comp
act U(1) in 3D and 4D, dual Abelian Higgs model) there are non-perturbative
contributions associated with short distances which are due to topological
defects. In QCD case, both classical and quantum effects determine the rol
e of the topological defects and the theoretical analysis has not been comp
leted so far. Generically, the topological defects would result in 1/Q(2) c
orrections going beyond the standard Operator Product Expansion. We review
existing data on the power corrections and find that the data favor existen
ce of the novel corrections, at least at the mass scale of (1-2) GeV. We in
dicate crucial experiments which could further clarify the situation on the
phenomenological side. (C) 2000 Elsevier Science B.V. All rights reserved.