Biotransformation of the Trichoderma metabolite 6-n-pentyl-2H-pyran-2-one by cell suspension cultures of Pinus radiata

Authors
Cooney, AM Hotter, GS Lauren, DR
Citation
Am. Cooney et al., Biotransformation of the Trichoderma metabolite 6-n-pentyl-2H-pyran-2-one by cell suspension cultures of Pinus radiata, PHYTOCHEM, 53(4), 2000, pp. 447-450
Citations number
16
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
53
Issue
4
Year of publication
2000
Pages
447 - 450
Database
ISI
SICI code
0031-9422(200002)53:4<447:BOTTM6>2.0.ZU;2-O
Abstract
Cell suspension cultures of Pinus radiata metabolize the antifungal Trichod erma secondary metabolite 6-n-pentyl-2H-pyran-2one (6PAP) (1) via hydroxyla tion of the pentyl side chain. Examination of the culture medium following dosing studies with 1 revealed that 79-85% of this bioactive compound had b een metabolised after 144 h. At that time, 34-40% of the metabolized dose w as recovered as a series of monohydroxylated isomers of 1, the principal me tabolite being 5-(2-pyron-6-yl)pentan-5-ol (7). (C) 2000 Elsevier Science L td. AII rights reserved.