Use of Midodrine and frozen/thawed semen to treat semen transport disturbances. Report of two cases

Retrograde ejaculation severely compromises male fertility. The use of symp athicomimetics for the treatment of this condition has poor results, except in patients with partial retrograde ejaculation, whose semen has a higher spermatozoa concentration. The semen of two patients with partial retrograd e ejaculation was collected and frozen after the injection of a sympathicom imetic (Midodrine). The frozen/thawed samples were mixed with fresh semen r ecently ejaculated to obtain a minimal number of motile spermatozoa, and us ed for intrauterine insemination (> de 1 x 10(6) motile spermatozoa/ml). In both cases, pregnancies that developed satisfactorily were obtained.