Global inequities in access to pharmaceutical products exist between rich a
nd poor countries because of market and government failures as well as huge
income differences. Multiple policies are required to address this global
drug gap for three categories of pharmaceutical products: essential drugs,
new drugs, and yet-to-be-developed drugs. Policies should combine "push" ap
proaches of financial subsidies to support targeted drug development, "pull
" approaches of financial incentives such as market guarantees, and "proces
s" approaches aimed at improved institutional-capacity. Constructive soluti
ons are needed that can both protect the incentives for research and develo
pment and reduce the inequities of access.