Peptide templated glycosylation reactions

Glycosyl donors and accepters may be covalently linked to aspartic acid res idues via OH-6 esters. Peptide elaboration allows glycosylation reactions t o be performed between donors and accepters linked to this peptide template . These reactions display increased regio- and stereoselectivities, which a re dependent on the nature of the peptide. Simple molecular modelling is us ed to rationalise the differing product distributions obtained by variation of the linking amino acid sequence. (C) 2000 Elsevier Science Ltd. All rig hts reserved.