Extra-pulmonary tuberculosis remains a diagnostic and therapeutic challenge
; its clinical presentation can mimic a wide range of pathological conditio
ns. Here we report on 3 female patients who presented with supra-sternal ma
sses that were suspected clinically to be of thyroid origin. By use of fine
-needle aspiration cytology (FNAC), they were proved to be tuberculous lesi
ons involving the pre-tracheal lymph nodes. Serological examination for HIV
-I/II was not reactive in the 3 patients. The patients responded well to a
regimen of multi-drug therapy. It is concluded that extra-pulmonary tubercu
losis should be considered in the differential diagnosis of thyroid or para
-thyroid swellings and that FNAC is a simple, quick and reliable procedure
in the diagnosis of extra-pulmonary tuberculous lesions involving the neck.