The dynamin family of mechanoenzymes: pinching in new places

Authors
McNiven, MA Cao, H Pitts, KR Yoon, Y
Citation
Ma. Mcniven et al., The dynamin family of mechanoenzymes: pinching in new places, TRENDS BIOC, 25(3), 2000, pp. 115-120
Citations number
54
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
25
Issue
3
Year of publication
2000
Pages
115 - 120
Database
ISI
SICI code
0968-0004(200003)25:3<115:TDFOMP>2.0.ZU;2-E
Abstract
The large GTPase dynamin is a mechanoenzyme that mediates the liberation of nascent clathrin-coated pits from the plasma membrane during endocytosis. Recently, this enzyme has been demonstrated to comprise an extensive family of related proteins that have been implicated in a large variety of vesicl e trafficking events during endocytosis, secretion and even maintenance of mitochondrial form. The potential contributions by the dynamin family to th ese diverse but related functions are discussed.