Galanin receptor subtypes

The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects. Pharmacological st udies using peptide analogues have led to speculation about multiple galani n receptor subtypes. Since 1994, a total of three G-protein-coupled recepto r (GPCR) subtypes for galanin have been cloned (GAL1, gal2 and gal3). Poten t, selective antagonists are yet to be found for any of the cloned receptor s. Major challenges in this field include linking the receptor clones with each of the known physiological actions of galanin and evaluating the evide nce for additional galanin receptor subtypes.