Comparison of in vitro activity of danofloxacin, florfenicol. oxytetracycline, spectinomycin send tilmicosin against Mycoplasma mycoides subspecies mycoides small colony type

Minimum inhibitory concentrations (MIC) and minimum mycoplasmacidal concent rations (MMC) Of the antimicrobials danofloxacin, florfenicol, oxytetracycl ine, spectinomycin and tilmicosin were determined in vitro for 20 isolates of Mycoplosma mycoides subspecies mycoides small colony type (MmmSC), the c ausative agent of contagious bovine pleuropneumonia (CBPP). The majority of strains were most susceptible to tilmicosin, followed by danofloxacin, oxy tetracycline, florfenicol and spectinomycin with MIC50 values of 0.015, 0.2 5, 0.5, 1 and 8 mu g/ml, and MMC50 values of 0.06, 0.5, 8, 8 and 16 mu g/ml , respectively. However, tilmicosin had poor mycoplasmacidal activity again st two recent strains from Portugal. There was no evidence of resistance to danofloxacin in any of the strains.