Jj. Rushton et al., SIMIAN-VIRUS-40 T-ANTIGEN CAN REGULATE P53-MEDIATED TRANSCRIPTION INDEPENDENT OF BINDING P53, Journal of virology, 71(7), 1997, pp. 5620-5623
A simian virus 40 (SV40) T-antigen mutant containing only the N-termin
al 136 amino acids, able to bind to Rb and p300 but not p53, partially
inhibited p53-mediated transcription without affecting the ability of
p53 to bind DNA. These results suggest that SV40 T antigen can regula
te p53-mediated transcription either directly through protein-protein
association or indirectly through interaction with factors which may f
unction to confer p53-mediated transcription.