Penile vibratory threshold changes with various doses of SS-cream in patients with primary premature ejaculation

SS-cream made with extracts from natural products is a topical agent for tr eating premature ejaculation (PE). In order to elucidate the penile vibrato ry threshold changes and clinical effects of various doses of SS-cream, 53 patients with primary PE were investigated in a double-blind randomized pla cebo-controlled study. The mean age was 37.3+/-6.4 years and mean ejaculato ry latency was 1.37+/-0.52 minutes. Neither the patients nor their sexual p artners were satisfied with their sexual lives. Vibratory threshold at the glans penis, penile shaft, scrotum and index finger were measured using a b iothesiometer twice during the screening period and three times one hour af ter the application of respective creams (SS-cream 0.05, 0.10. 0.15, 0.20 g m and placebo 0.10 gm) on the glans penis according to the order of the all ocation table in a randomized fashion. The efficacy of SS-cream was defined as when the vibration threshold increased by more than 4 microns compared to the value tested during the screening period. The vibratory thresholds a t the glans penis increased significantly in a dose-dependent manner after the application of various doses (0.05, 0.10. 0.15, 0.20 gm) of SS-cream (p <0.001), and the efficacy of SS-cream on the penile vibration threshold inc reased according to the increased dosage (penile shaft: 48.4, 51.6, 54.8, 6 4.5%, glans penis: 58.1, 67.7, 77.4, 83.9%, respectively). With these resul ts, Ne concluded that SS-cream increased the penile sensory threshold dose dependently, and therefore ir is clinically effective for treating the heig htened penile sensory response in patients with PE.