A case of nephrogenic diabetes insipidus caused by obstructive uropathy due to prostate cancer

Nephrogenic diabetes insipidus (DI) secondary to chronic urinary trace obst ruction is a rare disease, The exact cause is unknown but it is likely that increased collecting duct pressures cause damage to the tubular epithelium , resulting in insensitivity to the action of arginine-vasopressin (AVP). A 77-year-old man complaining of polyuria and polydipsia was created with al pha glucosidase inhibitor under the impression of polyuria due to diabetes mellitus. But his symptoms did not improve. Water deprivation and AVP admin istration study revealed chat the patient had nephrogenic DI. Urinary trace obstruction due to an enlarged prostate was suggested as a principal cause of nephrogenic DI. The patient underwent transurethral resection of the pr ostate and bilateral subcapsular orchiectomy. After surgery, the urine osmo larity was normalized and the patient became symptom-free. We report a case of nephrogenic DI due to obstructive uropathy which was cured by surgery e liminating obstruction.