Crystallization and preliminary X-ray diffraction studies of d(ACGTAGCTACGT)(2): [actinomycin D, (echinomycin)(2)] and d(ACGTAGCTACGT)(2): [actinomycin D, (triostin A)(2)] complexes

Authors
Takusagawa, HL Takusagawa, F
Citation
Hl. Takusagawa et F. Takusagawa, Crystallization and preliminary X-ray diffraction studies of d(ACGTAGCTACGT)(2): [actinomycin D, (echinomycin)(2)] and d(ACGTAGCTACGT)(2): [actinomycin D, (triostin A)(2)] complexes, ACT CRYST D, 56, 2000, pp. 344-347
Citations number
36
Categorie Soggetti
Chemistry & Analysis
Journal title
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
ISSN journal
09074449 → ACNP
Volume
56
Year of publication
2000
Part
3
Pages
344 - 347
Database
ISI
SICI code
0907-4449(200003)56:<344:CAPXDS>2.0.ZU;2-L
Abstract
A DNA-multiple drug complex, d(ACGTAGCTACGT)(2):[actinomycin D, (echinomyci n)(2)] has been crystallized, The crystals belong to the monoclinic space, group C2, with unit-cell parameters a = 85.6, b = 72.8, c = 56.6 Angstrom, beta = 101.5 degrees at 93 K and Z = 8, The crystal diffracted to 3.0 Angst rom resolution along the DNA fiber axis and to 3.5 Angstrom resolution in o ther directions. The Patterson maps indicate that all complexes in the crys tal are oriented along their helical axes in the [10(1) over bar] direction .