With the increase in detection at an early stage, only a few and conflictin
g results have been reported on the long-term outcome for prostate cancer b
eyond 10 years. The vast majority of prostate cancer patients diagnosed bet
ween 1955 and 1984 in southeastern Netherlands, with a population of almost
one million inhabitants, did not receive any curative treatment. We calcul
ated the prognosis for 10-year survivors of prostate cancer diagnosed in th
e era preceding prostate-specific antigen (PSA) testing to determine how lo
ng these patients exhibited excess mortality. All patients under age 70 dia
gnosed with prostate cancer and registered in the population-based Eindhove
n Cancer Registry between 1955 and 1984 were included in the study. Relativ
e survival was calculated for those who survived for at least 10 years (n =
174). Initially, these patients still exhibited an almost 25% excess morta
lity risk, but this decreased with time and no excess mortality was found a
fter 15 years.