Cortical laminar necrosis caused by immunosuppressive therapy and chemotherapy

We report three patients in whom neurologic symptoms and cortical laminar n ecrosis developed after immunosuppressive treatment (cyclosporin A and FK 5 06) and polychemotherapy (vincristine and methotrexate). Initial neuroradio logic studies showed cortical and white matter involvement. Follow-up studi es showed cortical hyperintense lesions on T1-weighted MR images, consisten t with cortical laminar necrosis, The clinical and radiologic data indicate that a transient hypoxic-ischemic process could have been responsible for the encephalic lesions in these three patients.