Simultaneous on-line dissolution monitoring of multicomponent solid preparations containing vitamins B1, B2

A unique stopped-flow flow injection analysis system for simultaneous synch ronous spectrofluorimetric on-line dissolution monitoring of multi-componen t solid preparations that makes use of a fiber-optic sensor was presented. A new means of in vitro therapeutic drug monitoring was developed by hyphen ating the fiber-optic sensor technique and a chemometric method. An artific ial neural network method was applied to construct the mathematical model f or the simultaneous analysis of the mixture of vitamins B-1, B-2 and B-6 by synchronous spectrofluorimetry. The selection of the wavelength interval, the pH of the carrier solution and other experimental conditions were inves tigated, and discussed. The proposed method has been applied to the dissolu tion monitoring of vitamin B tablets with satisfactory results. The recover y was 97.8-105%, and the relative standard deviation was 1.1-7.5%, The diss olution parameters of vitamins B-1, B-2 and B-6 in the vitamin B complex ta blets, which were derived from a best mathematical model using the proposed method, were furnished. The system could provide a profitable new techniqu e for simultaneous on-line process monitoring of therapeutic drugs and thei r metabolites in biological body fluids. (C) 2000 Elsevier Science B.V. All rights reserved.