TOTAL SYNTHESIS OF (+)-4-DEOXYGIGANTECIN

Authors
MAKABE H TANAKA A ORITANI T
Citation
H. Makabe et al., TOTAL SYNTHESIS OF (+)-4-DEOXYGIGANTECIN, Tetrahedron letters, 38(24), 1997, pp. 4247-4250
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
24
Year of publication
1997
Pages
4247 - 4250
Database
ISI
SICI code
0040-4039(1997)38:24<4247:TSO(>2.0.ZU;2-W
Abstract
(+)-4-Deoxygigantecin (1) was totally synthesized from enantiomericall y pure (-)-muricatacin (3). Thus, 3 afforded the key intermediate 5 th rough a five-step reaction sequence, which was then converted to (+)-4 -deoxygigantecin (1) via the formation of bis-tetrahydrofuran unit 1 1 and a coupling reaction with iodo lactone synthon 1 6. (C) 1997 Elsev ier Science Ltd.