METHYLENE ACETALS AS PROTECTING GROUPS - AN IMPROVED PREPARATION METHOD

Authors
GUISO M PROCACCIO C FIZZANO MR PICCIONI F
Citation
M. Guiso et al., METHYLENE ACETALS AS PROTECTING GROUPS - AN IMPROVED PREPARATION METHOD, Tetrahedron letters, 38(24), 1997, pp. 4291-4294
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
24
Year of publication
1997
Pages
4291 - 4294
Database
ISI
SICI code
0040-4039(1997)38:24<4291:MAAPG->2.0.ZU;2-7
Abstract
A facile method to protect vic diols, 1,3 diols and other hydroxyl fun ctions as methylene acetals is achieved by treating the relative subst ances with POCl3 or SOCl2 in DMSO. The good yields obtained, the good solubility of maw organic compounds in DMSO and the easy hydrolysis of the 1,3,5-trioxaepane derivatives prepared from trans vic diols make useful this protecting method. (C) 1997 Published by Elsevier Science Ltd.