A randomised British National Lymphoma Investigation trial of CHOP vs. a weekly multi-agent regimen (PACEBOM) in patients with histologically aggressive non-Hodgkin's lymphoma

Background: Between 1987 and 1991, the British National Lymphoma Investigat ion randomized 459 patients with non-Hodgkin's lymphoma with a large-cell c omponent to either CHOP or the PACEBOM regimen. Patients and methods: Four hundred fifty-nine eligible patients were includ ed in this trial, four hundred one with diffuse large-cell lymphoma and fif ty-eight with diffuse mixed-cell lymphoma according to the Working Formulat ion. Two hundred twenty-six patients were randomized to receive CHOP and tw o hundred thirty-three to receive PACEBOM. The two arms of the trial were w ell balanced for all potential prognostic factors. Results. The complete remission rate with PACEBOM was 64% and with CHOP 57% (NS). At eight years, the actuarial cause specific survival (CSS) in the P ACEBOM arm is 59% compared to 49% in the CHOP arm (P = 0.09). Patients < 50 years of age fared significantly better in the PACEBOM arm both for CSS an d overall survival (P = 0.002) and the CSS was also significantly improved in stage IV disease (P = 0.02). Conclusions: The mature data from this trial suggest that an etoposide-cont aining multi-agent weekly regimen can be superior to CHOP.