YAOUNDAMINE-A AND YAOUNDAMINE-B, NEW ANTIMALARIAL NAPHTHYLISOQUINOLINE ALKALOIDS FROM ANCISTROCLADUS-KORUPENSIS

Authors
HALLOCK YF CARDELLINA JH SCHAFFER M STAHL M BRINGMANN G FRANCOIS G BOYD MR
Citation
Yf. Hallock et al., YAOUNDAMINE-A AND YAOUNDAMINE-B, NEW ANTIMALARIAL NAPHTHYLISOQUINOLINE ALKALOIDS FROM ANCISTROCLADUS-KORUPENSIS, Tetrahedron, 53(24), 1997, pp. 8121-8128
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
24
Year of publication
1997
Pages
8121 - 8128
Database
ISI
SICI code
0040-4020(1997)53:24<8121:YAYNAN>2.0.ZU;2-6
Abstract
New monomeric naphthylisoquinoline alkaloids, yaoundamines A and B, we re isolated from Ancistrocladus korupensis and their structures were d etermined by extensive chemical and spectroscopic analyses. The absolu te configuration at C3 was established by chemical degradation, while the axial chirality was deduced by comparison of experimental and calc ulated CD spectra. Yaoundamine B has an unprecedented glycosylated nap hthylisoquinoline structure. Yaoundamines A and B are active in vitro against the malaria parasite Plasmodium falciparum. .