Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel mu opioid receptor ligands

Authors
Allen, MP Blake, JF Bryce, DK Haggan, ME Liras, S McLean, S Segelstein, BE
Citation
Mp. Allen et al., Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel mu opioid receptor ligands, BIOORG MED, 10(6), 2000, pp. 523-526
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
523 - 526
Database
ISI
SICI code
0960-894X(20000320)10:6<523:DSABEO>2.0.ZU;2-P
Abstract
3-Amino-3-phenylpropionamide derivatives were produced as small molecule mi mics of the cyclic octapeptide octreotide from readily available imine 1. T he compounds exhibit high affinity for the mu opioid receptor. (C) 2000 Els evier Science Ltd. All rights reserved.