The heterocyclic analogues of 5,6-dihydroxy-2-aminotetralins (6) were synth
esized and their in vitro dopaminergic activity was compared to that of (-)
-DP-5,6-ADTN and the novel potent agonist Z12571. The results show that cha
nging the cathecol ring for a heterocycle decreases the D-1-like activity o
f the target molecules 6. However, the D-2-like activity of tetrahydroquino
line (6j) was comparable to that of (-)-DP-5,6-ADTN. (C) 2000 Elsevier Scie
nce Ltd. All rights reserved.