Synthesis and dopaminergic activity of heterocyclic analogues of 5,6-dihydroxy-2-aminotetralins

Authors
Bosch, J Roca, T Perez, CG Montanari, S
Citation
J. Bosch et al., Synthesis and dopaminergic activity of heterocyclic analogues of 5,6-dihydroxy-2-aminotetralins, BIOORG MED, 10(6), 2000, pp. 563-566
Citations number
28
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
563 - 566
Database
ISI
SICI code
0960-894X(20000320)10:6<563:SADAOH>2.0.ZU;2-Q
Abstract
The heterocyclic analogues of 5,6-dihydroxy-2-aminotetralins (6) were synth esized and their in vitro dopaminergic activity was compared to that of (-) -DP-5,6-ADTN and the novel potent agonist Z12571. The results show that cha nging the cathecol ring for a heterocycle decreases the D-1-like activity o f the target molecules 6. However, the D-2-like activity of tetrahydroquino line (6j) was comparable to that of (-)-DP-5,6-ADTN. (C) 2000 Elsevier Scie nce Ltd. All rights reserved.