2-substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity

Authors
Kunick, C Schultz, C Lemcke, T Zaharevitz, DW Gussio, R Jalluri, RK Sausville, EA Leost, M Meijer, L
Citation
C. Kunick et al., 2-substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity, BIOORG MED, 10(6), 2000, pp. 567-569
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
567 - 569
Database
ISI
SICI code
0960-894X(20000320)10:6<567:2PCBPA>2.0.ZU;2-L
Abstract
9-Trifluoromethyl-paullones with a carbon chain in the 2-position were synt hesized by palladium-catalyzed coupling reactions of a 2-iodoprecursor with terminal alkenes or alkynes, respectively. The introduction of a 2-cyanoet hyl substituent led to a significant enhancement of CDK1/cyclin B inhibitin g property and in vitro antiproliferative activity. (C) 2000 Elsevier Scien ce Ltd. All rights reserved.