Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells

Authors
Schwede, F Brustugun, OT Zorn-Kruppa, M Dioskeland, SO Jastorff, B
Citation
F. Schwede et al., Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells, BIOORG MED, 10(6), 2000, pp. 571-573
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
571 - 573
Database
ISI
SICI code
0960-894X(20000320)10:6<571:MBAOCA>2.0.ZU;2-M
Abstract
We report an improved single-step synthesis to generate the membrane-permea nt acetoxymethyl esters (AM-esters) of cGMP and three cGMP-analogues. These bioactivatable compounds were found to induce cell death in rat IPC-81 cel ls, a model system for acute myelocytic leukemia, in micromolar doses, whil e the corresponding non-modified cGMP-analogues were inactive. (C) 2000 Els evier Science Ltd. All rights reserved.