Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation

Authors
Altomare, C Summo, L Cellamare, S Varlamov, AV Voskressensky, LG Borisova, TN Carotti, A
Citation
C. Altomare et al., Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation, BIOORG MED, 10(6), 2000, pp. 581-584
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
581 - 584
Database
ISI
SICI code
0960-894X(20000320)10:6<581:PDAIOP>2.0.ZU;2-8
Abstract
A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug t iclopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by adenosin 5'-di phosphate (ADP). Structure-activity relationships showed their antiplatelet effects to be related to the Lipophilicity. (C) 2000 Elsevier Science Ltd. All rights reserved.