Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine

Authors
Young, RJ Beams, RM Carter, K Clark, HAR Coe, DM Chambers, CL Davies, PI Dawson, J Drysdale, MJ Franzman, KW French, C Hodgson, ST Hodson, HF Kleanthous, S Rider, P Sanders, D Sawyer, DA Scott, KJ Shearer, BG Stocker, R Smith, S Tackley, MC Knowles, RG
Citation
Rj. Young et al., Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine, BIOORG MED, 10(6), 2000, pp. 597-600
Citations number
37
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
597 - 600
Database
ISI
SICI code
0960-894X(20000320)10:6<597:IOINOS>2.0.ZU;2-F
Abstract
The synthesis and in vitro evaluation of the acetamidine derivatives of het ero-substituted lysine and homolysine analogues have identified potent inhi bitors of human nitric oxide synthase enzymes, including examples with mark ed selectivity for the inducible isoform. (C) 2000 Elsevier Science Ltd. Al l rights reserved.