Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I-2 ligand

Authors
Coates, PA Grundt, P Robinson, ESJ Nutt, DJ Tyacke, R Hudson, AL Lewis, JW Husbands, SM
Citation
Pa. Coates et al., Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I-2 ligand, BIOORG MED, 10(6), 2000, pp. 605-607
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
605 - 607
Database
ISI
SICI code
0960-894X(20000320)10:6<605:PFIBSS>2.0.ZU;2-L
Abstract
An irreversible ligand (7) has been prepared based on the selective I-2 lig and 2-BFI. Compound 7 displayed high affinity and selectivity for I-2-sites and has been shown to irreversibly bind to these sites in rat brain. Compo und 7 should, therefore, prove an invaluable tool for the further elucidati on of I-2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved .