Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6-g]quinolines

Authors
Kong, JW Hamann, LG Ruppar, DA Edwards, JP Marschke, KB Jones, TK
Citation
Jw. Kong et al., Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6-g]quinolines, BIOORG MED, 10(5), 2000, pp. 411-414
Citations number
29
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
5
Year of publication
2000
Pages
411 - 414
Database
ISI
SICI code
0960-894X(20000306)10:5<411:EOIPRI>2.0.ZU;2-J
Abstract
A series of nonsteroidal human androgen receptor (hAR) antagonists based on 8-substituted 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoro methylpyrido[3,2-g]quinolines was synthesized. Compounds in this series wer e tested for the ability to bind to hAR and inhibit hAR-dependent transcrip tion in a mammalian cellular background. (C) 2000 Published by Elsevier Sci ence Ltd. All rights reserved.