Antimitotic activity of moroidin, a bicyclic peptide from the seeds of Celosia argentea

Authors
Morita, H Shimbo, K Shigemori, H Kobayashi, J
Citation
H. Morita et al., Antimitotic activity of moroidin, a bicyclic peptide from the seeds of Celosia argentea, BIOORG MED, 10(5), 2000, pp. 469-471
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
5
Year of publication
2000
Pages
469 - 471
Database
ISI
SICI code
0960-894X(20000306)10:5<469:AAOMAB>2.0.ZU;2-9
Abstract
A unique bicyclic peptide, moroidin (1), from the seeds of Celosia argentea (Amaranthaceae) strongly inhibited the polymerization of tubulin. The ster eostructure of moroidin (1) was reinvestigated by spectroscopic data, chemi cal degradation, and molecular dynamics simulation. (C) 2000 Elsevier Scien ce Ltd. All rights reserved.