The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives

Authors
Milkiewicz, KL Marsilje, TH Woodworth, RP Bifulco, N Hangauer, MJ Hangauer, DG
Citation
Kl. Milkiewicz et al., The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives, BIOORG MED, 10(5), 2000, pp. 483-486
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
5
Year of publication
2000
Pages
483 - 486
Database
ISI
SICI code
0960-894X(20000306)10:5<483:TDSAAO>2.0.ZU;2-B
Abstract
As part of a continuing effort to identify novel scaffolds that inhibit the pp60(c-src) protein tyrosine kinase, a series of hydroxyindole amides was rationally designed and synthesized. The most potent derivative was found t o bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd . All rights reserved.