Selection of a potent inhibitor of trihydroxynaphthalene reductase by sorting disease control data

Authors
Liao, DI Basarab, GS Gatenby, AA Jordan, DB
Citation
Di. Liao et al., Selection of a potent inhibitor of trihydroxynaphthalene reductase by sorting disease control data, BIOORG MED, 10(5), 2000, pp. 491-494
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
5
Year of publication
2000
Pages
491 - 494
Database
ISI
SICI code
0960-894X(20000306)10:5<491:SOAPIO>2.0.ZU;2-H
Abstract
Compounds that control rice blast, but not other crop diseases. a ere selec ted for testing as inhibitors of trihydroxy naphthalene reductase of the fu ngal melanin biosynthetic pathway. A potent inhibitor of the enzyme (2) (K- i = 25 nM) was identified. An X-ray structure of the enzyme-NADPH-2 complex was determined at 2.1 Angstrom resolution. (C) 2000 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.