Di. Liao et al., Selection of a potent inhibitor of trihydroxynaphthalene reductase by sorting disease control data, BIOORG MED, 10(5), 2000, pp. 491-494
Compounds that control rice blast, but not other crop diseases. a ere selec
ted for testing as inhibitors of trihydroxy naphthalene reductase of the fu
ngal melanin biosynthetic pathway. A potent inhibitor of the enzyme (2) (K-
i = 25 nM) was identified. An X-ray structure of the enzyme-NADPH-2 complex
was determined at 2.1 Angstrom resolution. (C) 2000 DuPont Pharmaceuticals
Company. Published by Elsevier Science Ltd. All rights reserved.