Solid phase synthesis of diamides as potential bone resorption inhibitors

Authors
Edvinsson, KM Herslof, M Holm, P Kann, N Keeling, DJ Mattsson, JP Norden, B Shcherbukhin, V
Citation
Km. Edvinsson et al., Solid phase synthesis of diamides as potential bone resorption inhibitors, BIOORG MED, 10(5), 2000, pp. 503-507
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
5
Year of publication
2000
Pages
503 - 507
Database
ISI
SICI code
0960-894X(20000306)10:5<503:SPSODA>2.0.ZU;2-X
Abstract
Unsymmetrical diamide libraries have been prepared by a general and versati le solid phase route, using diacid templates in combination with aromatic a nd aliphatic amines chosen with the help of statistical experimental design . The compounds were tested as potential inhibitors of osteoclast vacuolar ATPase. (C) 2000 Elsevier Science Ltd. All rights reserved.