Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives

Authors
Wells, G Bradshaw, TD Diana, P Seaton, A Shi, DF Westwell, AD Stevens, MFG
Citation
G. Wells et al., Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives, BIOORG MED, 10(5), 2000, pp. 513-515
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
5
Year of publication
2000
Pages
513 - 515
Database
ISI
SICI code
0960-894X(20000306)10:5<513:ABP1TS>2.0.ZU;2-I
Abstract
The synthesis of a series of new antitumour agents, the benzothiazole subst ituted quinol ethers and esters, is reported via the hypervalent iodine med iated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were f ound to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range. (C) 2000 Elsevier Science Ltd. Al l rights reserved.