Three patients with Mycobacterium marinum infection are described. Key elem
ents in the diagnosis of this infection are a high index of suspicion, taki
ng a history with an emphasis on exposure to tropical fish or other potenti
al sources of M. marinum infection, and tissue biopsy for culture and histo
logy. The microbiologist should be informed about the suspicion of M. marin
um infection so that appropriate cultures can be performed. As M. marinum d
oes not grow under routine culture conditions, the diagnosis is easily miss
ed resulting in delayed treatment. The treatment is essentially antimicrobi
al therapy for the superficial lesions supplemented by an appropriate surgi
cal debridement especially when deep structures are involved. (C) 2000 Harc
ourt Publishers Ltd.