Hysterosalpingo contrast sonography (HyCoSy) has been compared favourably i
n the literature with hysterosalpingography (HSG). It does not require ioni
zing radiation and demonstrates the uterus and ovaries. HyCoSy is reported
as being a safe, well tolerated, quick and easy investigation of Fallopian
tube patency. Over a 1-year period HyCoSy was performed by two operators on
118 consecutive women who were thought likely to have patent Fallopian tub
es. The examinations were graded using a local scale to assess discomfort a
nd were correlated with tubal patency. HSG was performed on 116 patients by
the same operators and discomfort recorded. 15 patients underwent both exa
minations. The degree of pain or reaction was graded 0 (no pain) to 4 (maxi
mum) according to a locally devised scale. Costs of the two examinations we
re estimated. 89 patients examined by HyCoSy were graded 0-2.However, 23 ha
d severe protracted pain and/or vasovagal reactions with bradycardia and hy
potension. Of these, seven required resuscitation owing to prolonged sympto
ms, requiring treatment with atropine. 19 of the 23 had bilaterally patent
Fallopian tubes. Where subsequent HSG was performed, tubal occlusion was co
nfirmed in 8 of 15 women. Other pathologies were noted in 29 of the HyCoSy
patients and there were six technical failures. During the same period no s
evere adverse reactions occurred in 116 patients having HSG performed by th
e same operators. Three of the HSG examinations were technically unsuccessf
ul. Discomfort following HyCoSy was much greater than that reported previou
sly. Possible mechanisms are discussed but it does not appear to be related
to tubal occlusion. Diagnostic accuracy, costs and discomfort compare unfa
vourably with HSG.