Three cases of intracranial Tl-201 uptake, reported as positive tumour acti
vity in patients with a final diagnosis of abscess, are described. Tl-201 h
as been proposed as a useful oncotropic radiotracer in the diagnosis of bra
in tumour activity. These cases suggest a note of caution in the interpreta
tion of Tl-201 brain images in the differential diagnosis of an intracrania
l expanding mass.