A review on the nonoperative removal of necrotic tissue from burn wounds

The study of nonoperative debridement of burns got underway during:thr Seco nd World War. A large number of substances such as enzymes of plant origin, acids and proteolytic enzymes:of bacterial origin were examined since. The proteolytic enzymes derived from filtrates of C, histolyticum and B, subti lis have attracted the greatest interest, Although enzymatic debridement wo uld seem at first sight to be an attractive form of treatment, unfortunatel y the results are highly variable. (C) 2000 Elsevier Science Ltd and ISBI. All rights reserved.