Involvement of insulin-like growth factor binding protein-3 in the retinoic acid receptor-alpha-mediated inhibition of hepatocellular carcinoma cell proliferation

Authors
Murakami, K Matsuura, T Hasumura, S Nagamori, S Yamada, Y Saiki, I
Citation
K. Murakami et al., Involvement of insulin-like growth factor binding protein-3 in the retinoic acid receptor-alpha-mediated inhibition of hepatocellular carcinoma cell proliferation, CANCER LETT, 151(1), 2000, pp. 63-70
Citations number
43
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
151
Issue
1
Year of publication
2000
Pages
63 - 70
Database
ISI
SICI code
0304-3835(20000403)151:1<63:IOIGFB>2.0.ZU;2-6
Abstract
We examined the relationship between the expression of retinoic acid recept or-alpha (RAR-alpha) and upregulation of insulin-like growth factor binding protein-3 (IGFBP-3) in the retinoid-induced inhibition of hepatocellular c arcinoma (HCC) cell proliferation. HCC cell Lines showed a marked expressio n of RAR-alpha, whereas the expression levels of RAR-beta and RAR-gamma wer e relatively lower. An RAR-alpha agonist significantly inhibited the HCC ce ll proliferation both in vitro and in vivo. The RAR-alpha expression closel y related to the upregulation of IGFBP-3 as compared with RAR-beta or RAR-a lpha expressions. RAR-alpha agonist would be beneficial to inhibit the grow th of HCC. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.